Originally established as a vocational-technical school, Mid-South Community College became a comprehensive community college in 1992. To help fund the conversion, MSCC asked Crittenden County voters to pass a property millage issue, and the citizens overwhelmingly approved the ballot measure in February 1993.
The college has enjoyed phenomenal enrollment growth since beginning the fall 1993 semester with 139 students. With a fall 2009 on-campus headcount of over 2,100, MSCC officially became the largest two-year institution in the Arkansas Delta. Major physical plant additions include the $12 million Donald W. Reynolds Center for Educational Excellence, the $7 million University Center, and the $6.5 million Workforce Technology Center.